Study: Retraining Cells May Reverse Brain Damage After Stroke

Cell therapy technology offers hope for unprecedented recovery, even days after stroke

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(COLUMBUS, Ohio) – Every 40 seconds, someone in the United States suffers a stroke. And though medical advancements have allowed doctors to clear blood clots in the brain, most ischemic stroke victims aren’t treated fast enough to prevent permanent damage. However, new technology developed at The Ohio State University Wexner Medical Center and The Ohio State University College of Engineering provides hope for unprecedented recovery by “retraining” skin cells to grow vascular cells and help repair  damage to brain tissue, even when administered days after a stroke.

“We rewrite the genetic code of skin cells that tell them to become blood vessel cells,” said Daniel Gellego-Perez, an assistant professor of biomedical engineering at The Ohio State University College of Medicine who is leading the research. “When they are deployed into the brain, they are able to grow new, healthy brain tissue to restore normal blood supply and repair damage.”

Researchers studied the process in mice and found that those treated with this innovative cell therapy regained 90 percent of their motor function. MRI imaging showed damaged areas of the brain were repaired within a few weeks.        

“The thought was that once brain tissue dies, that was it,” said Dr. Shahid Nimjee, a neurosurgeon at Ohio State University Medical Center and co-author of the study. “We’re now learning that there’s opportunities where we can regenerate cells to restore function to the brain.”

Researchers continue to study this approach and are also exploring other potential uses for this technology to treat brain disorders such as Alzheimer’s and autoimmune diseases. The findings are published online in the journal Science Advances. 

Images

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From left, researchers Ana Salazar Puerta, Jordan Moore and Natalia Higuita Castro helped develop a new cell therapy that reprograms cells to repair brain damage caused by ischemic stroke.

From left, researchers Luke Lemmerman and Daniel Gallego-Perez helped develop a new cell therapy that may lead to unprecedented recovery for stroke victims.

Dr. Shahid Nimjee studies cells engineered with specific DNA at The Ohio State University Wexner Medical Center. The new type of cell therapy has the potential to repair damage and grow healthy new brain tissue after ischemic stroke.

After suffering an ischemic stroke, Joseph Owens is working to fully regain his memory and speech, something that’s extremely important to him as a minister. New technology developed at The Ohio State University Wexner Medical Center and College of Engineering may help more stroke patients recover and regain function, even if they don’t receive treatment right away.

Graduate research associate Jordan Moore reviews brain MRI images of mice in the nanomedicine lab at The Ohio State University College of Medicine. In a new study, researchers demonstrate the potential of a new cell therapy to reverse damage from ischemic stroke by regrowing blood vessels and healthy brain tissue.


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